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Isatuximab binds to the CD38 epitope via its gamma heavy chains, inducing cell death through mechanisms such as antibody-dependent cellular cytotoxicity (ADCC) and apoptosis 146,147

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The variation in incidence rates of breast cancer between ethnic groups is already well established, including variations between patient subtypes, age of onset, and survival rates for people of both European, African, and Asian descent (93, 94)

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cytotoxicity data showed no toxicity to keratinocytes or fibroblasts across a six-log concentration range (0.0058 to 5800 micromolar) 3

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