Following sublingual administration, Drug A is 100 % bioavailable while following rectal administration, Drug A bioavailability is between 40 and 100 %, depending how far up the rectum the drug product is inserted Measurement of Bioavailability For intravenous injection, the whole of drug dose is delivered directly into the systemic circulation, thus it will always have 100 % bioavailability (F = 1) and the maximal plasma concentration (C max ) is reached instantaneously (T max = 0 min)
Lipids 181, 133
Pez-Franco JC, Torres-Ruiz J, Sosa-Hernndez VA, Cervantes-Daz R, Romero-Ramrez S, Prez-Fragoso A, et al
1) GSH (Regulator)
Pharmacokinetic and pharmacodynamic study of amodiaquine and its two metabolites after a single oral dose in human volunteers
This two-step injection protocol is known to induce OA-like cartilage degeneration, particularly in the lateral portion of the femoral condyle