The starting dose for Foundayo is 0.8 milligrams (mg), increasing to 2.5 mg after 30 days, and then to 5.5 mg after a further 30 days
Mice were maintained on a regular diet in a pathogen-free facility on a 12 h light/dark cycle with unlimited access to food and water
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Critically, both exercise modalities improve endothelial function through increased shear stress, which upregulates eNOS expression and NO bioavailability, thereby counteracting the endothelial dysfunction central to atherosclerosis (148)
TaqMan probe for Slc5a2 (Rn00574917_m1), Ctgf (Rn01537279_g1) and 18s (Rn03928990_g1) ribosomal RNA were purchased from Applied Biosystems (Foster City, CA, USA)
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