*FOR WEIGHT-LOSS MEDICATION BMI SOURCE: National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK)
Wang W, Mei A, Qian H, et al
Preliminary data and mechanistic understanding both suggest positive results, but the medical community rightly demands completed trials before making definitive claims
Front Pharmacol 2020;11:1270.ArticlePubMedPMC 84
To establish the T2DM model, after 8 weeks of HFD (10% lard, 20% sucrose, 2.5% cholesterol, 1% bile salt, and 66.5% regular diet), rats received the intraperitoneal (i.p.) injection of 35 mg/kg STZ (Sigma) after overnight fasting
For example, if the standard protocol calls for increasing from 2mg to 4mg after 4 weeks, a skin-sensitive individual might go from 2mg to 3mg, hold for 4 weeks, then move to 4mg