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Intranasal delivery, used with Selank and Semax, bypasses first-pass enzymatic metabolism in some systems, which partially explains why researchers observe longer effective durations than the IV values listed in typical half-life reference data

References 1.Tang C, Zhou K, Wu D, Zhu H

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Slight catheter movement during the infusion can also irritate the inner lining of the vein, causing redness and tenderness at the site