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According to the MHRA SmPC, semaglutide does not reduce the efficacy of hormonal contraceptives, though severe vomiting or diarrhoea may potentially affect the absorption of oral contraceptive pills, requiring temporary additional contraceptive measures

Semaglutide also has a longer half-life than the older GLP-1s and may have a stronger effect on receptors in the brain, which could help explain the difference in findings, Moreno adds

Call your doctor or nurse practitioners if you have any questions

Its reliability cannot be trusted even if it seems unchanged