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10.1016/j.neuron.2013.07.020 Neuron 98 JiD.WilsonM

Hepsin enhances liver metabolism and inhibits adipocyte browning in mice

Your body produces it naturally, primarily in the liver, but it is found in virtually every cell

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As a typical mitochondrial - targeted peptide, SS-31 (elamipretide) can stabilize cardiolipin in the inner mitochondrial membrane, reduce electron leakage to inhibit ROS, inhibit the opening of mPTP to reduce the release of mtDNA and cell apoptosis, protect mitochondria and exert anti - inflammatory effects, and is effective on immune cells and parenchymal cells such as cardiomyocytes

In this study, we provide a comprehensive clinical and neuropathologic characterization of an APP V717I mutation carrier, shedding new light on the phenotypic variability observed in ADAD cases (Lloyd et al., 2020)