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Three amino acid-altering GIP receptor variants (R190Q, E288G, and E354Q) are all associated with lower bone mineral density, and in postmenopausal women followed for 10 years, who were homozygous carriers of the E354Q variant, showed a higher risk of non-vertebral fractures (99, 101)

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Outlook and Analyst Commentary "We see ~6% upside to '26 M+Z ests," Morgan Stanley analysts commented, referring to projections for Mounjaro and Zepbound in 2026

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