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Maintaining Results While Continuing or Stopping GLP-1s A significant consideration for post-GLP-1 body contouring patients is long-term weight maintenance

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Deacon and colleagues, in Diabetologia, showed years ago that altering the end of a GLP-1 peptide makes it resist the DPP-4 enzyme, and that same principle is why retatrutide only needs a once-a-week shot under the skin

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Orforglipron also reduced non-HDL cholesterol, triglycerides and systolic blood pressure and decreased high-sensitivity C-reactive protein by 47.7%