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1 Iron overload profoundly affects the immune system by inhibiting the phagocytosis of macrophages and monocytes, increasing the number and viability of inhibitory T cells, limiting the proliferative ability of T helper cells, and changing the distribution of lymphocytes within the immune system

Likewise, ChREBP knockout protected against fructose-induced steatosis in mice, but substantially increased histological liver damage as a result of enhanced cholesterol synthesis and subsequent cytotoxicity [50]