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[2] Another important mechanism is its effect on mitochondria (the energy-producing parts of cells): MB can enhance mitochondrial efficiency at low doses, potentially improving cellular energy production while reducing oxidative stress

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found that oxidative stress in the synovium can promote glycolysis, which may help to accelerate the mechanism of inflammation (Balogh et al., 2018)

Free Radic Biol Med 1999;27:922-35

However, it's important to recognize that while a B12 deficiency may contribute to depression in some cases, it is not the sole cause