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A well-known marker of oxidative DNA damage, 8-OH-deoxyguanosine (8-OH-Gua), (see also above) of both nuclear and mitochondrial DNA, has also been found to be increased, which confirms damage caused by hydroxyl radicals (Abolhassani et al

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Research applications Research applications In vitro assays of ECM regulation (collagen, elastin) and MMP/TIMP balance Cell migration, proliferation, and cellular migration and tissue-matrix development models (fibroblasts, keratinocytes) Anti-inflammatory and antioxidant signaling studies (NF-B, Nrf2 pathways) Copper-dependent enzymatic and metalloregulator investigations Mechanistic combination studies with growth factors, cytokines, or small molecules For laboratory research use only

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Colonoscopy, mammography, Pap smears, PSA testing, and skin examinations as appropriate for age and risk factors detect cancers early when treatment is most effective