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FIGURE 5 3.5 Ferroptosis inducer Erastin abrogated the protective effects of ATT-I against DSS-induced colitis To further validate that the protective effects of ATT-I are mediated through ferroptosis inhibition, the ferroptosis inducer Erastin was co-administered with ATT-I in DSS-induced colitic mice

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Differential ability to stabilize free GSH may also explain why some studies report results as the ratio of free GSH to GSSG (e.g., [19, 22,23,24,25,26])