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The skin may become thickened, with reduced elasticity and increased susceptibility to infection (cellulitis), which can trigger acute inflammatory episodes and further compromise lymphatic function

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Vitamin C and Immunity Much of our immune system consists of mobile single cells that circulate with the blood or patrol our tissues looking for hostile invaders

Redox Biol 28:101343 Warren RB, Mrowietz U, von Kiedrowski R, Niesmann J, Wilsmann-Theis D, Ghoreschi K, Zschocke I, Falk TM, Bldorn-Schlicht N, Reich K (2017) An intensified dosing schedule of subcutaneous methotrexate in patients with moderate to severe plaque-type psoriasis (METOP): a 52 week, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

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