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EMA, 2023)

PLOS Comput

Unlike many GLP-1 agonist medications, Rybelsus is an oral medication

The peptide upregulates genes involved in extracellular matrix synthesis, tissue repair, and cellular proliferation while downregulating genes associated with inflammation, matrix degradation, and cellular senescence

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BuseJB,BainSC,MannJFE,NauckMA,NissenSE,PocockS,PoulterNR,PratleyRE,LinderM,Monk FriesT,rstedDD,ZinmanB;LEADER Trial Investigators