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Symptoms include severe abdominal pain radiating to the back

It is also possible that in active acromegaly, chronic exposure to elevated IGF-I levels resets IGF-IR responsiveness via the induction of IGF-IR resistance (70), as it has been demonstrated that prolonged stimulation with IGF-I induces functional IGF-IR resistance in vitro through the negative feedback loop (72)

Higher ("pharmacologic") doses are required to produce significant acceleration of growth in these conditions, producing blood levels well above normal ("physiologic")

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AOD-9604 originated from research at Monash University in the 1990s seeking to isolate the lipolytic domain of human growth hormone from its growth-promoting and metabolic-side-effect domains

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