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The Phase 2 trial showed 22.8% average body weight reduction at 48 weeks in the 8mg group

Retatrutide Effects on Each Receptor GIP Effect: Stimulating the GIP reduces stomach acid and a hormone called gastrin, which helps digest food

[1] [2] Traditionally administered via subcutaneous injection, some research has explored transdermal patch delivery systems as an alternative route of administration

Tirzepatide, the active ingredient in Eli Lilly's weight loss shot Zepbound and diabetes drug Mounjaro, mimics two of the hormones, GLP-1 and GIP

Metformin mainly reduces glucose production by the liver and improves insulin sensitivity