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In vivo, eight weeks of CJC-1295 DAC in four-month-old mice (10 mcg/kg subcutaneously, three times weekly) significantly increased the relative weight of the anterior pituitary gland, induced pituitary DNA damage, and significantly increased pituitary H2AX expression

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This protocol establishes standardized methodologies for evaluating this compound's bioactivity in cellular models relevant to atherosclerosis progression, particularly monocyte adhesion , macrophage foam cell formation , and endothelial dysfunction [1] [2]

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