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Interestingly, accumulation of -synuclein was found in intralysosomal sites within appendiceal mucosal CD68+ macrophages ( via DNA methylation of genes related to the production of autophagic protein and lysosomal degradation pathways (Figure 3A) (Lei et al., 2019)

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doi: 10.1016/j.bcp.2012.09.010