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The effects of the active forms of GLP-1 are mediated by a G protein-coupled receptor, GLP-1R, which is expressed in several sites, including enteric and vagal nerves, the stomach, pancreas, intestine, and various brain regions [15]

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BH2 enables BH4 regeneration, catalyzed by dihydrofolate reductase (DHFR) with NADP +/NADPH as cofactors

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