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Figure 4: Percentage of Nissl-positive neurons in each of the four different experimental groups included in the first part of the study

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doi: 10.1073/pnas.88.7.2825 41 KochMDiezJFritzG

Three principal amylin receptor subtypes exist [13] : AMY1 Receptor CTR + RAMP1 Primary receptor in area postrema (brainstem satiety center) [14] AMY2 Receptor CTR + RAMP2 Expressed in cardiovascular tissues and central nervous system [14] AMY3 Receptor CTR + RAMP3 Found in peripheral tissues including gastrointestinal tract [14] Cagrilintide binds to and activates these receptors with high affinity, triggering intracellular signaling cascades involving cyclic AMP (cAMP) and calcium mobilization [4]

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