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The specific mutants designed are as follows: for the Clathrin box, we introduced mutations K63E, I87D, Q89A and K98E (referred as the Cla mutant)

14 In pre-clinical research, formulations of tangerine peel not only inhibited insulin resistance and reduced hepatic lipid accumulation, but also improved markers of intestinal integrity and improved microbiota dysbiosis

The peptides compact structure and D-amino acid content contribute to resistance to enzymatic degradation