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When fluid intake decreases or fluid loss increases, urine becomes more concentrated, appearing darker yellow or amber rather than the pale straw colour typical of adequate hydration

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Environmental and Molecular Mutagenesis, 50(3), 266275

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These particles are aggregated peptide fragments and potentially other breakdown products

586,587 Similarly, reactive astrocytes are associated with -amyloid deposits in the brains of various transgenic AD models (most of which are models of hyperamyloidosis), although sometimes reactive remodelling of astrocytes precedes formation of -amyloid plaques