doi: 10.1016/j.lana.2024.100859 [DOI] [PMC free article] [PubMed] [Google Scholar]
The question now: Will oral GLP-1s make treatment as routine as a statinor spark the same payer battles we see with injectables
Other mechanisms that regulate the intracellular iron abundance, such as the exportation of iron via various multivesicular bodies and exosomes carrying ferroportin or prominin2-mediated ferritin, can also affect the cellular sensitivity to ferroptosis, as they deplete the cellular iron and accelerate the lipid peroxidation (53) ( Figure 1 )
Histone deacetylases (HDACs) are epigenetic regulators that modulate gene expression by removing acetyl groups from lysine residues on proteins, affecting processes like cell proliferation, differentiation, and development
Lcarnitine is best viewed as a small adjunct when combined with sensible diet and exercise rather than a standalone rapid weightloss solution
Conclusions and future perspectives Mitophagy, the selective degradation of mitochondria, plays a paradoxical role in PDAC
