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Similar agents such as iopanoic acid (10) and diatrizoate meglumine have been used at the doses described

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Two studies reported a significant reduction in lower limb amputations (LLA) and diabetic foot ulcers, while one study found no significant difference in LLA compared to other diabetic therapies

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Furthermore, it has been proposed that hyperglycemia elevates superoxide production, leading to the accelerated formation of advanced glycation end-products (AGEs)

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