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the steady state, but also possibly applicable to the measurement of cumulative oxidative damage)
Modestly higher homocysteine, as predicted by genetics, was associated with an increased risk of stroke .[ref] High homocysteine levels can damage the endothelium (lining of the blood vessels) and cause hardening of the arteries.[ref] Related article : Heart disease genes Chronic diseases: Similarly, MR studies have shown that high homocysteine can cause metabolic syndrome , worsen osteoarthritis , increase the risk of cataracts, and increase the risk of Alzheimers disease
The proposed mechanism includes modulation of oxidative stress and mitochondrial biogenesis
GSH is synthesized de novo in the brain by astrocytes and research has demonstrated increased GSH synthesis during oxidative stress-related toxicity in vitro , proposing in vivo synthesis of this antioxidant might be sufficient to not detect significant changes (14)
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