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2023;9(11):e21837

10.1002/jor.21147

Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

doi: 10.1093/rheumatology/keq108 183 AngiolilliCBaetenDLRadstakeTRReedquistKA

This neurological shift is essential for deep healing, as it allows the body to redirect cellular energy away from constant immune defense and toward tissue repair, digestion, and restorative sleep