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MNT incorporates individualized nutrition assessment, diagnostics, therapy, and counseling to modify dietary behaviors, manage health conditions, and enhance well-being [206]

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Mechanism of Action Triple receptor co-agonism: GLP-1R for appetite suppression and incretin effect, GIPR for improved insulin sensitivity, glucagon receptor for increased energy expenditure and hepatic fat oxidation addressing obesity through three distinct metabolic pathways simultaneously Target: GLP-1 receptor (GLP1R), GIP receptor (GIPR), Glucagon receptor (GCGR) Clinical trials demonstrate significant body weight reduction with sustained benefit Improves glycemic control and A1C levels in type 2 diabetes Associated with reduced cardiovascular events in high-risk patients Addresses multiple components of metabolic syndrome simultaneously These are commonly discussed research protocols not medical advice

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Both medications can lead to loss of lean muscle mass alongside fat, and adequate protein (0.7 to 1.0 grams per pound of body weight daily) helps preserve muscle

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See electronic supplementary material (ESM) Table 1 for ICD, and ESM Table 2 for Anatomical Therapeutic Chemical (ATC) codes used for covariates and drugs included in the study

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