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Patients are becoming so desperate for the product, last week the Federal Government announced an incoming ban on compounding pharmacies producing replicas of semaglutide and tirzepatide (sold as Mounjaro)

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A 2025 JACC Case Reports case documented an interaction consistent with this model: tirzepatide producing a 27 bpm supine heart rate increase in a POTS patient approximately nine times the mean reported in non-POTS populations attributed by the authors to compromised autonomic regulation of cardiac output distribution (Hedge et al., 2025)

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