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To generate HJEs, we took advantage of the bariatric surgery model with a cohort of 34 clinical characterized individuals divided into three groups according to the presence or absence of prediabetes or T2D

It belongs to the growth hormone-releasing peptide (GHRP) family and stimulates growth hormone release by binding to the ghrelin receptor (growth hormone secretagogue receptor, GHSR) on pituitary somatotroph cells

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10.1016/j.nantod.2008.10.014

They mimic the action of endogenous GLP-1, a hormone naturally released by cells in the small intestine in response to food intake and exert effects 16 (Figure 1) in a dose-dependent manner 17