Transactivation of NRF2 in KO livers was further supported by constitutive induction of NRF2 target genes, including Gclc , metallothionein I ( Mt1 ) and heme-oxgenase 1 ( Hmox1) (Fig
BMC Endocr Disord 23(1):230 Li X, Hou Y, Zou H, Wang Y, Xu Y, Wang L, Wang B, Yan M, Leng X (2024) Unraveling the efficacy of verbascoside in thwarting MRSA pathogenicity by targeting sortase A
Residue Rev., 66 : 102
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A common feature of many of these neurotoxic compounds, such as rotenone, paraquat, or MPTP, is the inhibition of mitochondrial complex I, followed by the overproduction of ROS, ATP exhaustion, and induction of a wide range of abnormalities that can elicit neuronal and astrocytic cell death [54]
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