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And regulatory approvals already reflect this shift: Wegovy is approved to lower cardiovascular risk, Ozempic slows kidney disease progression, and semaglutide is cleared for metabolic dysfunctionassociated steatohepatitis (MASH) with fibrosis

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Without enough protein, the body may cash out its savings and start breaking down muscle mass for fuel, Almandoz said

The underreported symptoms are leads that came from patients themselves, unprompted, and clinicians could potentially pay attention to them. Clinical trials generally identify the most dangerous side effects of drugs, says Lyle Ungar, professor in CIS and a co-author on the study