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Commenters stated that because MA rates are often based on Medicare FFS rates the proposal would over time lock in outdated weights in a closed loop that adds no independent information on these factors

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The changed gastric transit dynamics on tirzepatide may require dose adjustments monitored by thyroid labs

Research shows this small molecule is an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy regulation and fat metabolism