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Email: [email protected] Received: 03 November 2024 / Revised: 04 December 2024 / Accepted: 05 December 2024 / Published: 28 December 2024 DOI: 10.31491/APT.2024.12.158 Abstract Fibrotic disorders, such as idiopathic pulmonary fibrosis, are characterized by the accumulation of myofibroblasts, cells responsible for excessive extracellular matrix deposition and tissue remodeling

NLRP3 inflammasome suppression The NLRP3 inflammasome is molecular machinery responsible for assembling and activating the inflammatory response

Gut microbiota-derived trimethylamine-N-oxide inhibits SIRT1 to regulate SM22alpha-mediated smooth muscle cell inflammation and promote atherosclerosis progression

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The duration of action for tirzepatide and these newer compounds varies, which could eventually change dosing frequency and unit calculations

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