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Reduced renal or hepatic function warrants cautious dosing and closer monitoring

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All experimental findings consistently demonstrate that the therapeutic efficacy of MSCs for PH is regulated by three critical factors

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Since decreased Parasutterella relative abundance may accompany increased stress 80,81 , the increased Parasutterella relative abundance that occurred in this study following diet switch likely arose from the weight loss-mediated negative energy state

Its hypermethylation and down-regulated expression may contribute to higher IMF content