Well, thank you so much, Marisha
In the resting state, MOTS-c exhibits a predominantly extranuclear localization pattern, but when cells were subjected to metabolic stress (glucose restriction, serum deprivation, or oxidative stress), MOTS-c was found to rapidly translocate into the nucleus as early as 30 min after stress induction, and return to its basic extranuclear state within 24 h [36]
Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, et al
Furthermore, this interplay is well exemplified by the findings of previous studies that showed that administration of pan-caspase inhibitor, zVAD-fmk potentially facilitated RIPK-mediated necroptosis in several renal models including AKI induced by CP (Linkermann et al., 2013
RLS is a subset of Periodic Limb Movement Disorder (PLMD) aka nocturnal myoclonus
Semaglutida, liraglutida y tirzepatida