SURMOUNT-2 was a multi-centre, randomised, double-blind, parallel, placebo-controlled trial comparing the efficacy and safety of tirzepatide 10mg and 15mg to placebo as an adjunct to a reduced-calorie diet and increased physical activity in adults with obesity or overweight and type 2 diabetes
These are recognised class effects associated with GLP-1based therapies
PEG has considerable side effects, however, including nausea, flatulence, and diarrhea, particularly in older individuals (Leung, Riutta 2011
Genetic Insights: Optimizing Your Tirzepatide Response with Precision Testing The PlexusDx Precision Peptide Genetic Test ($99 add-on after your first month) analyzes GLP1R (rs6923761), GIPR (rs1800437), FTO (rs9939609), and MC4R (rs17782313) variants that relate to GLP-1 and related signaling pathways
Cagrilintide has been evaluated in receptor-binding and pathway modulation research
Circ Res 121(7):731748