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In reserpinized animals, the number of squares crossed, grooming, raising, sniffing, and mobile time were considerably reduced, while the central immobility time was significantly enhanced compared to the control group

B., & Smith, A

WHO Media Centre, 2012

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However, the magnitude of some of these observational estimates (for example, relative reductions in cardiovascular or all-cause mortality exceeding 50%) is considerably larger than would be predicted from the randomized effect sizes of either class and is almost certainly inflated by residual and time-related confounding, including healthy-adherer and prevalent-user biases