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Because its a water-soluble vitamin, any excess that isnt used should be flushed from the body and not pose too much risk (not the case with fat-soluble vitamins like vitamin A)

PKA closes adenosine triphosphate (ATP)-dependent potassium (KATP) channels, depolarizes -cell membranes, and opens voltage-dependent calcium channels

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There are 2 types of melanin called 1

This question often comes up in the context of energy drinks and supplements that add vitamin B12 to their formulas