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The SURMOUNT-1 trial reported average reductions of up to 22% with tirzepatide over 72 weeks

Fiber intake, adequate hydration, and physical activity are the foundations of digestive management during the transition

Res 72 , 603612 (2003)

In addition, unlike DPP-4 inhibitors, the GLP-1 agonists slow gastric emptying, increase satiety and promote modest weight loss [5, 10, 11]

Interestingly, these same animals have an improvement of their glucose tolerance in response to oral DPP-IV treatment, but not to subcutaneous GLP-1 mimics, indicating how the former relies completely on localized, non -cell GLP-1R (215)

GLP-1 receptor agonists slow gastric emptying, potentially leaving food in the stomach beyond standard fasting periods