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[ [PMID: 27581696]

73 In summary, peripheral administration of GLP-1RAs either acts directly on the hypothalamus and hindbrain, which lack BBB, or directly crosses the BBB into CNS, which are then projected to other key feeding areas of the brain (Figure 6)

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43 In this regard, bimagrumab, a monoclonal antibody against activin II receptors, has been trialled in people with T2D and obesity, resulting in 6.5 per cent weight loss over 48 weeks, alongside a 3.6 per cent increase in muscle mass ( Figure 1 )

Adjust the environment of the GLP-1RAs@NPs solution to a microenvironment similar to that of RA and shake it on a shaker at 37 C