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SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus

3.2.2 TGF--induced mitochondrial ROS production Mitochondria are the primary intracellular source of ROS, and TGF-1 markedly enhances their production across multiple cell types, contributing to apoptosis, senescence, epithelialmesenchymal transition (EMT), and fibrotic gene expression associated with myofibroblast differentiation [58]

Dasgupta Q, Jiang A, Wen AM, Mannix RJ, Man Y, Hall S

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