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The reality of oral administration for musculoskeletal indications is straightforward: the peptide disperses through the digestive system before it reaches the injury site, and what arrives at a tendon or joint after that journey is a fraction of what a subcutaneous injection placed near the tissue delivers

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Qiu Y, Zhang J, Liu Y, Ma H, Cao F, Xu J, Hou Y, Xu L (2013) The combination effects of acetaminophen and N-acetylcysteine on cytokines production and NF-B activation of lipopolysaccharide-challenged piglet mononuclear phagocytes in vitro and in vivo