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It is not surprising that EtPhCbl and PhEtyCbl both exhibit diculty in dissociating the upper axial ligand as these cobalamins have been shown to be metabolically inert

Leclercq, S

They can be used intermittently and are a popular therapy for exhaustion, burn out, migraines and of course post-party nausea

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Similarly, cyclosporin A, a well-characterized immunosuppressive agent, has demonstrated protective effects against APAP-induced hepatotoxicity when administered in combination with NAC in murine models

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