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In conclusion, GLP-1-based therapy emerges not merely as a promising option but as a currently available, evidence-supported pharmacological strategy for MC4R -deficient obesity in regions where these agents are accessible

that reported that oral L-carnitine administration could not significantly reduce lp(a) concentration in type IIdiabetic patients [44]

Other targets/mechanisms must therefore be considered

Subgroup and Sensitivity Findings Analyses stratified by age, sex, SGLT2 inhibitor co-use, and cardiovascular risk revealed no significant heterogeneity, supporting the external validity of the findings across typical clinical populations

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