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This included Israel Simon Kleiner and Samuel Meltzer, two American physiologists, based at the Rockefeller University in New York who in 1915 demonstrated with animal experiments the power of intravenously administered pancreatic extracts in lowering blood sugar

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[DOI] [PubMed] [Google Scholar] 96.Storoni M, Chan CK, Cheng AC, Chan NC, Leung CK

From a mechanistic perspective, sulfonylureas may facilitate tumor formation and progression via their insulin secretagogue properties [102]

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