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A separate analysis found that semaglutide users had significantly lower 30-day, 3-month, and 1-year risk of joint-related outcomes, including stiffness, pain, swelling, and synovitis, compared to nonusers

However, a crucial limitation of the above studies is that the endpoint was pathologic (described as asymptomatic chronic pancreatitis), referring to histologic changes, rather than clinical 26

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