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When calorie intake is reduced, as it often is with GLP-1 medications, protein needs may increase

The question of how long to stay on GLP-1 therapy takes on new dimensions when you factor in organ protection beyond weight maintenance

Researchers found that the difference in the time it took for half of ingested food to move from the stomach to the small intestine was just 36 minutes longer for patients taking GLP-1 medications, a relatively small amount of time compared to the standard periprocedural fasting period of eight hours

In fact, there are reports which demonstrate that administration of both a probiotic microorganism strain and prebiotics influences GLP-1 release and signaling

Several ranking pages call this out directly

Diabetes 61 , 888896 (2012)