Yes, based on Phase 3 data
COMT is a gene which does multiple, multiple things, but one of which is helps break down dopamine
Manganese peptide complexes (e.g., manganese tripeptide-1) have been explored as alternatives that avoid copper-related skin discoloration concerns while providing metal-dependent enzymatic activation
[19] One author later stated "the research is, by definition, not independent of the funder, because they selected the question"
What a Herxheimer Reaction Feels Like Patients experiencing a Herxheimer reaction may report: Increased fatigue Worsening brain fog Muscle or joint pain Flu-like symptoms Sleep disruption Dizziness or head pressure Mood shifts or anxiety These symptoms can resemble a flare-up or relapse, which adds to the confusion
It depends on your goals and where your levels are starting