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Numerous GLP-1 receptor-targeting drugs have been investigated in clinical studies for various indications, including type 2 diabetes and obesity (accounts for 70% of the total studies), non-alcoholic steatohepatitis, Alzheimer's disease, and Parkinson's disease

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These mitochondrial alterations are accompanied by changes in nuclear-encoded mitochondrial gene expression, suggesting epigenetic regulation of cellular energy metabolism pathways (49)